Effective Improvement of Symptoms in Patients with Acute Migraine by GR43175 Administered in Dispersible Tablets

GR43175, a selective 5-HT1-like agonist, was administered as oral dispersible tablets in an open, uncontrolled dose-ranging study to assess its efficacy as an agent for acute migraine. Nine patients, all with well established attacks, were assessed for changes in severity of headache and associated symptoms over 2 h. Drug absorption was compared during and between attacks in five patients. Doses of 140 mg and 280 mg resulted in complete relief of all symptoms within 2 h. Treatment was well tolerated in all patients

Grasping the concept of personal property.

The concept of property is integral to personal and societal development, yet understanding of the cognitive basis of ownership is limited. Objects are the most basic form of property, so our physical interactions with owned objects may elucidate nuanced aspects of ownership. We gave participants a coffee mug to decorate, use and keep. The experimenter also designed a mug of her own. In Experiment 1, participants performed natural lifting actions with each mug. Participants lifted the Experimenter's mug with greater care, and moved it slightly more towards the Experimenter, while they lifted their own mug more forcefully and drew it closer to their own body. In Experiment 2, participants responded to stimuli presented on the mug handles in a computer-based stimulus-response compatibility task. Overall, participants were faster to respond in trials in which the handles were facing in the same direction as the response location compared to when the handles were facing away. The compatibility effect was abolished, however, for the Experimenter's mug - as if the action system is blind to the potential for action towards another person's property. These findings demonstrate that knowledge of the ownership status of objects influences visuomotor processing in subtle and revealing ways

A Spin-Orbit Alignment for the Hot Jupiter HATS-3b

We have measured the alignment between the orbit of HATS-3b (a recently discovered, slightly inflated Hot Jupiter) and the spin-axis of its host star. Data were obtained using the CYCLOPS2 optical-fiber bundle and its simultaneous calibration system feeding the UCLES spectrograph on the Anglo-Australian Telescope. The sky-projected spin-orbit angle of $\lambda = 3\pm25^{\circ}$ was determined from spectroscopic measurements of Rossiter-McLaughlin effect. This is the first exoplanet discovered through the HATSouth transit survey to have its spin-orbit angle measured. Our results indicate that the orbital plane of HATS-3b is consistent with being aligned to the spin axis of its host star. The low obliquity of the HATS-3 system, which has a relatively hot mid F-type host star, agrees with the general trend observed for Hot Jupiter host stars with effective temperatures $>6250$K to have randomly distributed spin-orbit angles.Comment: 13 pages. Accepted for publication in the Astrophysical Journa

SuperLupus: A Deep, Long Duration Transit Survey

SuperLupus is a deep transit survey monitoring a Galactic Plane field in the Southern hemisphere. The project is building on the successful Lupus Survey, and will double the number of images of the field from 1700 to 3400, making it one of the longest duration deep transit surveys. The immediate motivation for this expansion is to search for longer period transiting planets (5-8 days) and smaller radii planets. It will also provide near complete recovery for the shorter period planets (1-3 days). In March, April, and May 2008 we obtained the new images and work is currently in progress reducing these new data.Comment: 3 pages, 2 figures, to appear in the Proceedings of IAU Symposium 253, 2008: Transiting Planet

Examining the broadband emission spectrum of WASP-19b: A new z band eclipse detection

WASP-19b is one of the most irradiated hot-Jupiters known. Its secondary eclipse is the deepest of all transiting planets, and has been measured in multiple optical and infrared bands. We obtained a z band eclipse observation, with measured depth of 0.080 +/- 0.029 %, using the 2m Faulkes Telescope South, that is consistent with the results of previous observations. We combine our measurement of the z band eclipse with previous observations to explore atmosphere models of WASP-19b that are consistent with the its broadband spectrum. We use the VSTAR radiative transfer code to examine the effect of varying pressure-temperature profiles and C/O abundance ratios on the emission spectrum of the planet. We find models with super-solar carbon enrichment best match the observations, consistent with previous model retrieval studies. We also include upper atmosphere haze as another dimension in the interpretation of exoplanet emission spectra, and find that particles <0.5 micron in size are unlikely to be present in WASP-19b.Comment: 10 pages, 8 figures, 2 tables, accepted for publication in Ap

MSc environmental consultancy placement case studies

Edited collection of case studies of placement

An adaptive pseudo-spectral method for reaction diffusion problems

The spectral interpolation error was considered for both the Chebyshev pseudo-spectral and Galerkin approximations. A family of functionals I sub r (u), with the property that the maximum norm of the error is bounded by I sub r (u)/J sub r, where r is an integer and J is the degree of the polynomial approximation, was developed. These functionals are used in the adaptive procedure whereby the problem is dynamically transformed to minimize I sub r (u). The number of collocation points is then chosen to maintain a prescribed error bound. The method is illustrated by various examples from combustion problems in one and two dimensions

Measurement of the Nodal Precession of WASP-33 b via Doppler Tomography

We have analyzed new and archival time series spectra taken six years apart during transits of the hot Jupiter WASP-33 b, and spectroscopically resolved the line profile perturbation caused by the Rossiter-McLaughlin effect. The motion of this line profile perturbation is determined by the path of the planet across the stellar disk, which we show to have changed between the two epochs due to nodal precession of the planetary orbit. We measured rates of change of the impact parameter and the sky-projected spin-orbit misalignment of $db/dt=-0.0228_{-0.0018}^{+0.0050}$ yr$^{-1}$ and $d\lambda/dt=-0.487_{-0.076}^{+0.089}$~$^{\circ}$ yr$^{-1}$, respectively, corresponding to a rate of nodal precession of $d\Omega/dt=0.373_{-0.083}^{+0.031}$~$^{\circ}$ yr$^{-1}$. This is only the second measurement of nodal precession for a confirmed exoplanet transiting a single star. Finally, we used the rate of precession to set limits on the stellar gravitational quadrupole moment of $9.4\times10^{-5}<J_2<6.1\times10^{-4}$.Comment: Published in ApJL. 5 pages, 3 figures. Corrected error in the calculation of J_

Ks band secondary eclipses of WASP-19b and WASP-43b with the Anglo-Australian Telescope

We report new Ks band secondary eclipse observations for the hot-Jupiters WASP-19b and WASP-43b. Using the IRIS2 infrared camera on the Anglo-Australian Telescope (AAT), we measured significant secondary eclipses for both planets, with depths of 0.287 -0.020/+0.020% and 0.181 -0.027/+0.027% for WASP-19b and WASP-43b respectively. We compare the observations to atmosphere models from the VSTAR line-by-line radiative transfer code, and examine the effect of C/O abundance, top layer haze, and metallicities on the observed spectra. We performed a series of signal injection and recovery exercises on the observed light curves to explore the detection thresholds of the AAT+IRIS2 facility. We find that the optimal photometric precision is achieved for targets brighter than Kmag = 9, for which eclipses as shallow as 0.05% are detectable at >5 sigma significance.Comment: Accepted for publication in MNRAS, 13 pages, 10 figure